Cui-Wei Xie Laboratory:
[Publications]

Our primary research interests are the modulation of synaptic plasticity in the hippocampus and its alterations under pathological conditions. Current projects investigate the effects of opioid peptides and Alzheimer’s amyloid ß (Ab ) peptides on hippocampal long-term potentiation (LTP), long-term depression (LTD) and function of NMDA receptor channels. Our objectives are to determine how these peptides affect the long-term synaptic plasticity, what are the intracellular signaling pathways transducing their effects, and ultimately how these processes contribute to the development of opioid addiction or memory loss in Alzheimer's disease. Another aspect of our research is the modulatory effect of opioids on voltage gated ion channels in sensory neurons and its desensitization. The major approaches used in the lab are electrophysiological recordings from brain slices and cultured neurons, in combination with calcium imaging, immunocytochemical and molecular techniques through collaborations with other labs in the Center.

Laboratory Phone: (310)206-2946


Laboratory Staff:

Miao Tan, Ph.D. (Postdoctoral Fellow) Email:   mtan@ucla.edu

Danyun (Alice) Zhao, M.D. (Research Technician) Email:   azhao@mednet.ucla.edu

Cui-Wei Xie, M.D., Ph.D.
Associate Professor

Email:
xiexy@ucla.edu

Phone:
(310)206-0083